PRANADERM ALGISOL

• Arnica is recognized for its analgesic and anti-inflammatory effect in topical use; useful in sprains, bruises, arthralgias and localised muscular pains.
• Topical plantain has a topical immunomodulatory and anti-inflammatory effect that fosters tissue healing and repair.
• Comfrey works by promoting anti-inflammatory and tissue repair processes.
• Ginkgo improves the microcirculation and oxygenation of tissues, an essential effect for the mobilisation of toxins and cellular vitality.
• The aloe extract has a wound healing, anti-inflammatory and immunomodulatory action.

Each components, in detail:

ALOE VERA: Aloe has wound healing, anti-inflammatory, immunomodulatory and antiviral properties which are all the result of the synergistic action of the various constituents. Wound healing is primarily due to direct stimulation of the activity of macrophages and fibroblasts. The latter promote an increase in the synthesis of collagen and proteoglycans and, as a consequence,promoting the repair of the damaged tissue. Acemannan and, more recently, aloeride have been described as the main compounds responsible for the immunomodulatory action. In first- and second-degree thermal burns, fresh aloe vera gel used topically has shown superior efficacy over other conventional treatments. Due to its content in mucilages, it has moisturising and emollient properties, useful in both therapeutics and cosmetics.

ARNICA:This has anti-inflammatory, analgesic,Nantiplatelet, antihistaminic and antibacterialNproperties.NThe arnica flower has shown activity in acuteNand chronic inflammation models.  The European Medicines Agency (EMA) approves its traditional use (in topical application) for the relief of bruises, sprains and localised muscular pains. According to ESCOP, the arnica flower is indicated for the topical treatment of haematomas, sprains and inflammation.

COMFREY: The comfrey root has anti-inflammatory and healing properties. In vitro studies performed with various comfrey alcoholic extracts demonstrate the inhibition of the arachidonic acid activation pathway and the classical pathway of complement activation. This effect is in part related to rosmarinic acid. Healing properties have been demonstrated in experimental animal studies and in vitro, and are related to the content of allantoin and mucilages. ESCOP recommends the external use of comfrey preparations for the treatment of sprains, contusions, strains, osteoarthritis, epicondylitis and periarthritis. The European Medicines Agency (EMA) approves the traditional use of topical preparations based on this root for the treatment of sprains and minor bruises.

GINKGO:  Ginkgo extract has antioxidant activity due to its free radical uptake and inhibition of the generation of reactive oxygen species. This action has been linked to the prolongation of the half-life of nitric oxide (relaxation factor derived from the endothelium) which leads to vascular relaxation and vasodilation. The compounds responsible for the antioxidant activity known so far are mainly the flavonoids and the terpenes.

PLANTAIN:  The steroids found in the plantain inhibit the release of arachidonic acid from phospholipid stores and thus block the release of leukotrienes, prostaglandins and thromboxanes, and prevent the migration of leukocytes and monocytes to the affected area. All this contributes to its anti-inflammatory and therefore, analgesic, effect. The German Commission E recognizes its external use for inflammatory conditions of the skin.